glutathione metabolic process pathways. GCL, glutamate cysteine ligase; GST, Study proposes a new strategy

This reaction uses a methyl group, which ties into the methylation cycle (more on this later)

Asparagine synthetase in normal and malignant tissues: correlation with tumor sensitivity to asparaginase

Conducted at Centre Hospitalier de Bretagne Sud, Lorient, France

Dysregulated iron homeostasis constitutes the fundamental basis for ferroptosis initiation ( 4.1 Molecular pathways governing ferroptosis cell death Iron is a critical driver of lipid peroxidation and subsequent ferroptosis within cellular environments ( Diminished activity of the cystine/glutamate antiporter (system Xc-) serves as the initial trigger for ferroptosis ( Ferroptosis substrates primarily include polyunsaturated fatty acids (PUFAs, characterized by their abundance of double bonds), free polyunsaturated fatty acids such as oxidized arachidonic acid, and adrenal hormones